Xeomin vs. Botox: Similarities, Differences, Side Effects, Costs

Are you considering cosmetic treatments for wrinkles and fine lines but feeling overwhelmed by the number of options available? Xeomin and Botox are two popular options that work by temporarily relaxing the muscles that cause them. This article compares the two treatments, including their similarities, differences, side effects, costs, and post care instructions so you can make an informed choice about which treatment is best for you.

What is Xeomin?

Xeomin (INCObotulinumtoxin A) was first approved by the FDA in 2010 to treat blepharospasm, or involuntary blinking, and cervical dystonia, an involuntary contraction of the neck muscles. In 2015, it was approved for the treatment of upper extremity spasticity and in 2018, for the treatment of chronic gonorrhea. Xeomin is manufactured by Merz Pharmaceuticals, using a unique precision manufacturing process that separates the therapeutic component from the molecule and removes unnecessary proteins that do not play an active role in the treatment process.

What is Botox?

Botox (ONAbotulinumtoxin A) was first approved by the FDA as a temporary cosmetic treatment to improve the appearance of frown lines in April 2002. Botox, or onabotulinumtoxinA, is a product of Irish drugmaker Allergan and currently has about 80% of the market for BoNT-A injections. With a molecular weight of 900 kDa, Allergan produces botulinum toxin type A with protective proteins to which a small group of patients may develop antibodies over time, thereby reducing the effectiveness of treatment.

What are The Similarities Between Xeomin and Botox?

Xeomin and Botox Cosmetic are both neurotoxins that work by temporarily blocking nerve signals to muscles. This causes the muscles to relax, which can reduce the appearance of wrinkles and prevent new ones from forming.

What are The Differences Between Xeomin and Botox?

Xeomin and Botox are both effective at reducing the appearance of wrinkles and are administered in the same way. However, there are certain differences between the two that can make Xeomin more effective than Botox.


Xeomin is a highly purified form of botulinum toxin type A, while Botox contains other proteins in addition to the active ingredient. This difference in formulation may make Xeomin less likely to cause allergic reactions than Botox.

Complexing Proteins

The manufacturing process of Botox differs from that of Xeomin in that Botox contains a complexing protein whereas Xeomin is produced without such a protein. The purpose of the complexing protein present in Botox is believed to facilitate the distribution of the product through the muscle tissue more evenly, however, this may also increase the likelihood of side effects.


The effects of both Xeomin and Botox typically last for several months, but some studies have shown that Xeomin may last slightly longer. With Xeomin, the body doesn’t put up as strong of resistance to the effects of the neurotoxin so the patients may have outcomes that last longer compared to Botox.


According to a study published by the National Institutes of Health, both treatments produce similar results four months after the injections. That said, Xeomin has been shown to produce results faster than Botox largely due to the formulation of each treatment. Botox contains an inactive ingredient called accessory proteins that act as a preservative, meaning the body must break down the protein for the effects to be felt. Xeomin, on the other hand, is a purer version of the neurotoxin. The active ingredients in Xeomin work immediately, and the effects show up after just a few days.


Xeomin is typically more affordable than Botox at our Brooklyn medspa. Our Xperience+ loyalty program offers $50 OFF toward qualifying treatments. Xeomin pricing is based on the number of units of injection required for treatment, or the areas that require treatment.

Xeomin for Frown Lines – 14 days before and after

What are The Possible Side Effects of Xeomin and Botox?

Xeomin has slightly different ingredients than Botox, which could affect how likely you are to develop resistance. But they’re pretty much the same when it comes to safety. The possible side effects are temporary and usually related to the injections. You can expect some pain, bruising and swelling at the site of the injection. Risk of developing these side effects can be reduced if you do not take anti-inflammatory medication before your appointment.

What Should You Avoid After Injections?

First 24 Hours

Avoid strenuous exercise, heavy drinking, and too much sun exposure during the first 24 hours following treatment. This will help reduce the risk of adverse reactions and ensure optimal results.

First Few Days

The effects of treatment generally become apparent within a couple of days, with peak efficacy occurring approximately one to two weeks after treatment. During this period, it is recommended to avoid rubbing or massaging treated areas to avoid the spread of neurotoxin to undeserved areas.

Follow-Up Appointments

Our medical injectors may suggest additional follow-up sessions to evaluate the outcomes of your treatment plan and objectives, as well as to determine the need for additional touch-up injections. These follow-ups may take place several weeks after the completion of the initial treatment.

Long-Term Care

To maintain your results, follow our medical injector’s post-treatment care guidelines. For example, you may want to avoid sun exposure, stay hydrated, and use the right skincare products.

How Do I Get Started With Xeomin Treatment at Medical Spa in Brooklyn, New York?

Do you want to get rid of wrinkles and look more youthful and attractive today? Book an appointment for a Xeomin treatment at our Brooklyn medical spa or schedule a free consultation with our medical injector. We are committed to providing our patients with the best care possible and we look forward to hearing from you!

Contact us at (929) 615-9762 or email@facelabmedicalspa.com to schedule your consultation.

Disclaimer: Individual results may vary. Consult our experienced medical injectors to tailor the ideal treatment plan for your unique requirements.